Published July 1988
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Biodistibution of 2,6 diisopropyliminodiacetic acid 99mTc (Disida-99mTc) in normal rats and with experimental hepatic lesion
Description
The biodistribution and elimination of 99mTc-DISIDA were examined by performing scintigrams on rats at different times. Normal animals (rats) and those with experimental hepatobiliary alterations were used. Results showed a delayed clearance of 99mTc-DISIDA into the small intestine of the experimental animals. The elimination of the labelled compound by the kidney was 14% dose/g 120 minutes after the injection of which 70% was found in its original form. The data indicate that in spite the compound is intact in bile it undergoes a degradative process, not yet known. (author)
Abstract (Portuguese)
A biodistribuicao e eliminacao do DISIDA- 99mTc foram estudadas em ratos por meio de cintilografia linear em diversos tempos da sua evolucao metabolica. Os animais utilizados na deteccao deste radiofarmaco foram ratos normais e com alteracao hepatica experimental. Verificou-se uma demora na passagem do DISIDA- 99mTc do figado ao intestino delgado nos ratos pre-tratados em relacao aos ratos normais. Seguindo-se a via metabolica hepato-biliar da substancia marcada, notou-se que embora esteja praticamente intacta atraves da bile, ela sofre um processo de degradacao ainda desconhecido, sendo eliminada via renal com 70% da sua integride 120 minutos apos a administracao da dose tracadora. (autor)Files
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Additional details
Additional titles
- Original title (Portuguese)
- Biodistibuicao do acido 2.6 diisopropiliminodiacetico-
Publishing Information
- Imprint Pagination
- 15 p.
- Report number
- IPEN-PUB--176
INIS
- Country of Publication
- Brazil
- Country of Input or Organization
- Brazil
- INIS RN
- 19092355
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- IMINES; LIVER; METASTABLE STATES; MICE; RADIONUCLIDE KINETICS; SCINTISCANNING; TECHNETIUM 99
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; ENERGY LEVELS; EXCITED STATES; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES