Published July 1982
| Version v1
Journal article
Simple labeling of ω-phenylfatty acids by iodine isotope exchange
Description
Within 1h 15-(p-iodophenyl)-pentadecanoic acid (p-IPPA) can easily be labeled with 123I by iodine-isotope exchange. In contrast to the electrophilic aromatic substitution procedure this method enables a 95% radiochemical yield. The so formed p-123IPPA can be used without the application of any complicated separation techniques. By comparison with commercially available 17-[123I]iodoheptadecanoic acid (123IHA) p-123IPPA shows a remarkably higher uptake in a rabbit heart. Additionally the background activity of p-123IPPA proved to be lower than that measured with 123IHA. p-123IPPA thus indicating its suitability for routine applications in nuclear medical heart diagnosis. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Appl. Radiat. Isot.
- Journal Volume
- 33
- Journal Issue
- 7
- Series
- Int. J. Appl. Radiat. Isot.
- Journal Page Range
- 499-504
- ISSN
- 0020-708X
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 14723393
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBOXYLIC ACIDS; CHEMICAL REACTION YIELD; HEART; IODINE 123; ISOTOPIC EXCHANGE; LABELLING; RABBITS; RADIOPHARMACEUTICALS; UPTAKE
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; VERTEBRATES