Fine structural observation on repair processes in experimental ulcer of the rat gastric mucosa

Experimental stomach ulcer of the rat was produced by clamping method. Repair processes of the epithelial and glandular cells were examined by LM, SEM, TEM and autoradiograph with 3H-thymidine at various times after removal of the clamp. The epithelial cells in the vicinity of the defect consisted of the surface cells with a few mucous granuls, parietal cells, endocrine cells and fibrillovesicular cells of Hammond and LaDuer during repair processes. The chief cells appeared after 12 days. After 5 weeks, the defect was completely covered with the epithelium. All kind of the epithelial cells except fibrillovesicular cells can incorporate thymidine precursor during regeneration. (author)