Published April 1991 | Version v1
Journal article Metadata-only

Synthesis of carbon-11 labelled calcium channel antagonists

Creators

  • 1. Kernforschungsanlage Juelich GmbH (Germany). Inst. fuer Medizin

Description

A useful synthetic approach to carbon-11 labelled 1,4-dihydropyridines is described. Carbon-11 labelled calcium channel antagonists 11C-Nifedipine, 11C-Nisoldipine, 11C-nitrendipine and 11C-CF3-Nifedipine were synthesized by a modified Hantzsch method using protected carboxy functions. Deprotection of the carboxylic acids by alkaline hydrolysis followed by conversion into the corresponding potassium salts and subsequent methylation with 11CH3I produced the labelled compounds in very good chemical and radiochemical yields (94%). (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
29
Journal Issue
4
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
431-442
ISSN
0362-4803
CODEN
JLCRD

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
23010642
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CARBON 11; CHEMICAL PREPARATION; HYDROLYSIS; LABELLING; METHYL IODIDE; METHYLATION; POSITRON COMPUTED TOMOGRAPHY; PYRIDINES; RADIOPHARMACEUTICALS
Descriptors DEC
AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHEMICAL REACTIONS; COMPUTERIZED TOMOGRAPHY; DECOMPOSITION; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SOLVOLYSIS; SYNTHESIS; TOMOGRAPHY