Action of prolonged treatment with cod liver oil on certain biochemical changes in rats exposed to fractionated gamma irradiation

The effect of prolonged treatment of rats with cod liver oil in modifying the radiation induced changes in the level of glucose, pyruvic acid, lactic acid and the activity of lactate dehydrogenase (LDH) in serum of irradiated rats were studied. Emulsion of liver oil was orally administered every day for a period of 4 weeks. The daily administered dose was 1ml emulsion containing 857 ng vitamin A, 7.2 ng vitamin D and 875 ng vitamin E/100 g body weight. The rats were whole body gamma irradiated at fractionated doses up to Gy (4 equal fractions, 2 Gy weekly) and the first radiation fraction was given to rats at the end of the first week of treatment with cod liver oil. The data obtained revealed that treatment of normal rats with cod liver oil did not induce any significant changes in the levels of the parameters studied (glucose, pyruvic acid and lactic acid) as well as in the activity of LDH during all the experimental time periods (1, 7, 14 and 30 days post treatment)