Effects of irradiation on the anterior pituitary of young rats
Creators
- 1. Nara Medical Univ., Kashihara (Japan)
Description
We examined irradiation-induced damage to the anterior pituitary of young rats, particularly to the folliculo-stellate (F-S) cells. The whole brain of 3-week-old Wistar rats (n=24), was irradiated once with a linear accelerator (Linac). The pituitary gland was removed after sacrifice and fixed in formalin. Pituitary specimens were stained with hematoxylin and eosin (H and E), or immunostained for S-100 protein, growth hormone (GH), and adrenocorticotropic hormone (ACTH) by the ABC technique. Angiogenesis in the chronic stage after irradiation was related to an increase of F-S cells in the subacute stage. The decrease in GH cells and ACTH cells after irradiation was dose-dependent, with more severe irradiation-induced damage being in GH cells than in ACTH cells. (author)
Additional details
Publishing Information
- Journal Title
- Shoni No Noshinkei
- Journal Volume
- 19
- Journal Issue
- 2
- Journal Page Range
- p. 117-122.
- ISSN
- 0387-8023
- CODEN
- SHONDL
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 25072633
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ACTH; BRAIN; DOSE-RESPONSE RELATIONSHIPS; NECROSIS; PARTIAL BODY IRRADIATION; PITUITARY GLAND; RADIATION DOSES; RADIATION INJURIES; RATS; STAINS; STH
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DISEASES; ENDOCRINE GLANDS; EXTERNAL IRRADIATION; GLANDS; HORMONES; INJURIES; IRRADIATION; MAMMALS; NERVOUS SYSTEM; ORGANS; PATHOLOGICAL CHANGES; PEPTIDE HORMONES; PITUITARY HORMONES; RADIATION EFFECTS; RODENTS; VERTEBRATES