Radiobiological effects of 110In versus 111In in rat testis
- 1. University Hospital, Lund (Sweden)
- 2. Uppsala Univ. (Sweden). Svedberg Lab.
Description
Induction of radiobiological effects after intratesticular (IT) injection of 110In-oxine or 111In-oxine in Wistar rats were evaluated in the present report. These two radionuclides were chosen because of their different energy deposition patterns. 110In is almost a pure β emitter with no Auger electron emission, whereas 111In emits conversion electrons and Auger electrons. The retention of 111In activity in the testis was measured with a scintillation camera and 110In with a collimated HpGe detector. Measurements were performed immediately after IT injection and repeated over several half-lives. Time-activity curves were generated for each animal and these were used for absorbed dose calculations. The resulting D37 values for spermhead survival were approximately 1.9 Gy for 110In-oxine, and 2.2 Gy for 111In-oxine
Additional details
Publishing Information
- Publisher
- American Inst. of Physics, Inc.
- Imprint Place
- Woodbury, NY (United States)
- ISBN
- 1-56396-095-8
- Imprint Title
- Biophysical aspects of Auger processes. American Association of Physicists in Medicine symposium proceedings No. 8
- Imprint Pagination
- 426 p.
- Journal Page Range
- p. 273-289.
Conference
- Title
- 2. international symposium on biophysical aspects of Auger processes.
- Dates
- 5-6 Jul 1991.
- Place
- Amherst, MA (United States).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 26040637
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- AUGER EFFECT; BIOLOGICAL MODELS; BIOLOGICAL RADIATION EFFECTS; COMPARATIVE EVALUATIONS; INDIUM 110; INDIUM 111; RADIONUCLIDE KINETICS; TESTES; TISSUE DISTRIBUTION
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; EVALUATION; GONADS; HOURS LIVING RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MALE GENITALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIATION EFFECTS; RADIOISOTOPES
Optional Information
- Secondary number(s)
- CONF-9107281--.