Production process for high specific activation-corresponding-type 13NH3 labelled agent

An aqueous 13NH3 solution is subjected to a cation exchange and dehydration drying to form anhydrous 13NH3. The obtained anhydrous 13NH3 is dissolved in an organic solvent or an organic solvent containing a reaction substrate and subjected to labelling reaction to prepare high specific activity type 13N labelled compound. In the cation ion exchange treatment, alkali-leaching is conducted to purify the 13N labelled compound thereby preparing a physiological formulation. A device for manufacturing a high specific activity-type 13N labelled compound comprises a cation exchange treatment portion for an aqueous solution of 13NH3, a dehydration-drying portion, a reaction portion for conducting dissolution of the anhydrous 13NH3 in an organic solvent and reacting it with the reaction substrate. A manufacturing device for enabling automatic synthesis further comprises a detection means and a control means. High specific activation overcoming the limit of 13N in existent labelled agents is possible by the preparation of highly anhydrous 13NH3 solution, and various kinds of novel 13N labelled agents which can be also utilized for the study of receptor in PET can be synthesized automatically. (N.H.)