The importance of monitoring minimal residual disease in childhood acute lymphoblastic leukemia
Creators
- 1. Klinika detskej hematologie a onkologie LF UK a DFNsP, Bratislava (Slovakia)
- 2. Oddelenie lekarskej genetiky, Narodny onkologicky ustav, Bratislava (Slovakia)
- 3. Detske onkologicke oddelenie DFNsP, Banska Bystrica (Slovakia)
- 4. Oddelenie detskej hematologie a onkologie DFN, Kosice (Slovakia)
Description
Since the strong correlation between minimal residual disease (MRD) levels and risk of relapse in childhood acute lymphoblastic leukemia, monitoring of MRD provides unique information regarding treatment response. Because the significance of MRD monitoring has been strongly supported by several studies and because it has been implemented in the latest protocols, there has been a significant effort to develop MRD monitoring in the Slovak Republic. Between 1. 10. 2006 and 31. 12. 2009, 50 children with ALL who were treated at three Slovak centers were included in the RQ PCR MRD pilot project. Based on MRD stratification, we identified 26 patients who were stratified into the HRG (high risk group) 3 patients (11,5 %), IRG (intermediate risk group), 14 p. 54 % and SRG (standard risk group), 9 p. (34,5 %). (author)
Additional details
Additional titles
- Original title (Slovak)
- Vyznam monitorovania minimalnej rezidualnej choroby pre detskej akutnej lymfoblastovej leukemii
Publishing Information
- Journal Title
- Onkologia (Bratislava)
- Journal Volume
- 7
- Journal Issue
- 2
- Journal Page Range
- p. 137-140
- ISSN
- 1336-8176
INIS
- Country of Publication
- Slovakia
- Country of Input or Organization
- Slovakia
- INIS RN
- 48087559
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CHEMOTHERAPY; LEUKEMIA; LYMPHOMAS; RADIOLOGY; SARCOMAS; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; DISEASES; IMMUNE SYSTEM DISEASES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; THERAPY
Optional Information
- Notes
- 20 refs., 2 figs., 2 tabs.