Bone marrow distribution in patients with hematologic malignancy; degree of bone marrow extension and uptake ratio

We evaluated the distribution pattern and uptake ratio of bone marrow using anti-NCA-95 monoclonal antibody in patients with various hematologic malignancy. Bone marrow immunoscintigraphy was performed on 50 patients; 11 with acute myelogenous leukemia (AML), 12 with acute lymphocytic leukemia (ALL), 15 with lymphoma (LYM) and 2 myelogenous syndrome (MDS). The bone marrow activity was categorized into four groups (G): I, II, III, IV. The degree of bone marrow extension was 0 in Gl, 7 in GII, 3 in GIII, 1 in GIV of AML patients; 0 in GI, 5 in GII, 6 in GIII, 1 in GIV of ALL patients; 3 in GI, 11 in GII, I in GIII, 0 in GIV of LYM patients; 1 in G1, 4 in GII, 5 in GIII, 2 in GIV of MDS patients. Bone marrow extension was marked in MDS patients (58% in GIII, GIV), mil in LYM patients (93% in GI, GII) and heterogenous in leukemic (AML, ALL) patients. UR was 5.9±3.6 in AML patients, 7.9±4.6 in ALL patients, 6.3±2.8 in LYM patients and 8.5±4.0 in MDS patients (p=NS). UR of whole patients was 5.4 ±2.6 in GI, 7.1±3.7 in GII, 9.3±3.4 in GIII and 2.1±0.4 in GIV (p=0.003). The pattern of bone marrow extension was different among the disease entities. Activity of central hemopoietic marrow was related to the degree of bone marrow extension, but not to the disease entities. Compensatory response of bone marrow developed at both peripheral and central skeleton in patients with hematologic malignancy