Chemical impurities in [18F]FDG preparations produced by solid-phase 18F-fluorination

[18F]FDG was produced by solid-phase 18F-fluorination (resin method) and chemical impurities were determined in the [18F]FDG preparations by ion chromatography. The major chemical impurities were D-glucose (90.5±6.4 μg/mL), 2-chloro-2-deoxy-D-glucose (11.8±2.7 μg/mL), and D-mannose (1.7±0.7 μg/mL), which were expected to be present by considering the synthetic routes. An FDG mass (0.5±0.2 μg/mL) was also detected in the preparations. No notable radiochemical impurities, including 2-[18F]fluoro-2-deoxy-D-mannose, were detected in the [18F]FDG preparations. Thus, the levels of several chemical impurities were determined in the [18F]FDG preparations produced by solid-phase 18F-fluorination