Published December 2008 | Version v1
Journal article Metadata-only

Effect of tripanossomicide benznidazole (Rochagan) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats

Creators

  • 1. Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil). Centro de Ciencias da Saude
  • 2. Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil). Centro de Biociencias. Dept. de Microbiologia e Parasitologia
  • 3. Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil). Dept. de Estatistica

Description

Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole. (author)

Availability note (English)

Available from http://www.scielo.br/pdf/babt/v51nspe/v51nspea28.pdf

Additional details

Identifiers

URL
http://www.scielo.br/pdf/babt/v51nspe/v51nspea28.pdf;

Publishing Information

Journal Title
Brazilian Archives of Biology and Technology
Journal Volume
51
Journal Issue
special number
Journal Page Range
p. 175-180
ISSN
1516-8913

Conference

Title
6. Congress of the Brazilian Society of Nuclear Biosciences - New trends in radiopharmaceutical applications
Original Conference Title
6. Congresso da Sociedade Brasileira de Biociencias Nucleares - SBBN2008. Novas tendencias nas aplicacoes dos radiofarmacos
Acronym
SBBN2008
Dates
11-13 Dec 2008
Place
Cabo Frio, RJ (Brazil)

INIS

Country of Publication
Brazil
Country of Input or Organization
Brazil
INIS RN
40040626
Subject category
S60: APPLIED LIFE SCIENCES;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BENZIMIDAZOLES; IN VIVO; RADIOPHARMACEUTICALS; RATS; TECHNETIUM 99; TISSUE DISTRIBUTION; TRYPANOSOMA
Descriptors DEC
ANIMALS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DISTRIBUTION; DRUGS; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; IMIDAZOLES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; INVERTEBRATES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MASTIGOPHORA; MATERIALS; MICROORGANISMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PARASITES; PROTOZOA; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
refs., 2 tabs.