Technetium-99m-labeled p-aminohippuric acid analog: a new renal agent; concise communication
Creators
- 1. Albert Einstein Coll. of Medicine, Bronx, NY
Description
A renal agent labeled with Tc-99m and quantitatively secreted by the tubules has been sought for many years. To meet this need, a PAH analog (PAHIDA), has been synthesized by the coupling of p-aminohippuric acid with nitrilotriacetic acid anhydride, using Sn(II) reduction. The purity and stability of the Tc-99m complex have been established by ITLC and high performance liquid chromatography (HPLC). Urinary excretions of the Tc-99m PAHIDA and I-131 hippurate, determined in mice and rats at different time intervals, are similar. The new compound is clearly excreted but its total clearance is lower than that of hippurate as a result of high protein binding. The Tc-99m-labeled agent is rapidly excreted in urine with no significant extrarenal pathway, thus providing excellent renal scintigrams in a rabbit model
Additional details
Publishing Information
- Journal Title
- J. Nucl. Med.
- Journal Volume
- 25
- Journal Issue
- 10
- Series
- J. Nucl. Med.
- Journal Page Range
- 1111-1115
- ISSN
- 0022-3123
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 16034705
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AMINO ACIDS; BLOOD-PLASMA CLEARANCE; CHELATING AGENTS; CHEMICAL PREPARATION; HIPPURIC ACID; IODINE 131; ISOMERIC NUCLEI; KIDNEYS; NTA; RABBITS; RADIOPHARMACEUTICALS; RATS; SCINTISCANNING; TECHNETIUM 99; TISSUES; TUBULES
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CLEARANCE; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; SYNTHESIS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES