Published March 2006
| Version v1
Journal article
A new technique for labeling of [11C]-choline, a positron-emitting tracer for tumor imaging
- 1. PET Center, Beijing (China). PLA General Hospital
- 2. Normal University, Beijing (China). Dept. of Chemistry
Description
[11C]-choline has been reported as a potential tracer for imaging a variety of human tumors with positron emission tomography (PET). A new labeling technique for [11C]-choline was established depending on parameters optimized, such as reaction time, volume, temperature, and the quantity of DMAE. The synthesis yield was improved from 82.0% to 96.5% (EOB), while the consumption of DMAE precursor decreased from 60 to 2 mg. Absolute yield of [11C]-choline was 2500 MBq for a 10-minute irradiation at 15 μA, and a total synthesis time of less than 8 minutes from [11C]-CH3I to [11C]-choline. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Radioanalytical and Nuclear Chemistry
- Journal Volume
- 267
- Journal Issue
- 3
- Journal Page Range
- p. 665-668
- ISSN
- 0236-5731
- CODEN
- JRNCDM
INIS
- Country of Publication
- Hungary
- Country of Input or Organization
- Hungary
- INIS RN
- 37051587
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CARBON 11; CHEMICAL PREPARATION; CHEMICAL REACTION KINETICS; CHOLINE; LABELLING; NEOPLASMS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS
- Descriptors DEC
- ALCOHOLS; AMINES; AMMONIUM COMPOUNDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; HYDROXY COMPOUNDS; ISOTOPES; KINETICS; LABELLED COMPOUNDS; LIGHT NUCLEI; LIPOTROPIC FACTORS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; QUATERNARY COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; REACTION KINETICS; SYNTHESIS; TOMOGRAPHY
Optional Information
- Notes
- 18 refs.