Published February 2013
| Version v1
Journal article
Free radical scavenging potential anilinoacridines and acridinylhydrazides
- 1. International Centre for Chemical and Biological Sciences, Karachi (Pakistan)
- 2. Comsats Inst. of Information Technology, Abbottabad (Pakistan). Dept. of Chemistry
- 3. Pakistan Council of Scientific and Industrial Research Labs., Karachi (Pakistan)
Description
Summary: Anilinoacridines and acridi nylhydrazides derivatives 1-29 have been screened for their in vitro DPPH free radical scavenging activity. Compounds 19 (IC 50 = 22.15 macro M), 16 (IC 50 = 24.95 macro M), and 17 (IC 50 = 34.23 micro M) showed an excellent antioxidant potential superior to standard t -butyl-4-hydroxyanisole (IC50 = 44.7 micro M). A structure-activity relationship has been developed and it has been found that compounds 16, 17 and 18 possess allylic carbon which upon abstraction of hydrogen radical becomes more stable mesomerically. (author)
Additional details
Publishing Information
- Journal Title
- Journal of the Chemical Society of Pakistan
- Journal Volume
- 35
- Journal Issue
- 1
- Journal Page Range
- p. 202-205
- ISSN
- 0253-5106
INIS
- Country of Publication
- Pakistan
- Country of Input or Organization
- Pakistan
- INIS RN
- 44063145
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ACRIDINES; ANTIOXIDANTS; IN VITRO; ISCHEMIA; LIPIDS; RADICALS; SCAVENGING
- Descriptors DEC
- ANEMIAS; AROMATICS; AZAARENES; AZINES; CARDIOVASCULAR DISEASES; DISEASES; HEMIC DISEASES; HETEROCYCLIC COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIDINES; SYMPTOMS; VASCULAR DISEASES