Published February 1978 | Version v1
Journal article Metadata-only

Measurement of post-irradiation population kinetics using single-cell cytophotometry combined with double-labeling autoradiography

Creators

  • 1. Koeln Univ. (Germany, F.R.). Pathologisches Inst.
  • 2. Koeln Univ. (Germany, F.R.). Radiologisches Inst. und Poliklinik

Description

A technique for in vivo determination of the population kinetics in tumors following irradiation is reported in this paper. Using the model of a diploid Ehrlich adcites tumor, the migration of cells from different subpopulations was followed up through the generation cycle. The measurability of post-irradiation growth kinetics in different subpopulations is emphasized with regard to its importance for practical application with combination treatments or possibility for the problem of dose-time relations. The individual results obtained after 475 rd are presented in detail. (orig.)

Abstract (German)

In der vorliegenden Arbeit wird ueber ein Verfahren zur in-vivo-Bestimmung der Populationskinetik von Tumoren nach Bestrahlung berichtet. An dem Modell eines diploiden Ehrlich-Aszites-Tumors wurde die Wanderung von Zellen verschiedener Subpopulationen durch den Generationszyklus verfolgt. Es wird auf die Bedeutung der Messbarkeit der Wachstumskinetik verschiedener Subpopulationen nach Bestrahlung im Hinblick auf eine praktische Anwendung durch Kombinationsbehandlungen bzw. eine moegliche Bedeutung fuer das Dosis-Zeit-Problem hingewiesen. Die einzelnen nach 475 rd erhaltenen Ergebnisse werden ausfuehrlich dargestellt. (orig.)

Additional details

Additional titles

Subtitle (English)
Model investigations into a diploid Ehrlich ascites tumor after 475 rd X-irradiation
Original title (German)
Die Messung der Populationskinetik nach Bestrahlung durch Kombination von Einzelzellzytophotometrie und zweiseitiger Markierungsautoradiographie
Original subtitle (German)
Modelluntersuchungen an einem diploiden Ehrlich-Aszites-Tumor nach 475 rd Roentgenbestrahlung.

Publishing Information

Journal Title
Strahlentherapie
Journal Volume
154
Journal Issue
2
Series
Strahlentherapie.
Journal Page Range
107-116

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
9395049
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
AUTORADIOGRAPHY; BIOLOGICAL RADIATION EFFECTS; CARBON 14 COMPOUNDS; CELL CYCLE; DNA; DOSE-RESPONSE RELATIONSHIPS; DOUBLE LABELLING; EXPERIMENTAL NEOPLASMS; IN VIVO; KINETICS; MICE; MITOTIC INDEX; THYMIDINE; TIME DEPENDENCE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; TUMOR CELLS; WHOLE-BODY IRRADIATION; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; AZINES; BIOLOGICAL EFFECTS; CARBON COMPOUNDS; DISEASES; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; ISOTOPE APPLICATIONS; LABELLING; MAMMALS; NEOPLASMS; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RIBOSIDES; RODENTS; VERTEBRATES

Optional Information

Notes
11 figs.; 1 tab.; 21 refs.