Degree of tumor vascularization as predictor of response to nonadjuvant combination chemotherapy for breast cancer

A procedure for obtaining microcirculation coefficient is described. It is based on the phenomenon of formation of a focus of radionuclide hyperfixation on scintigrams of tumor area due to embolization of its arterioles and precapillaries with radionuclide. The method was used in 26 breast cancer patients before neoadjuvant chemotherapy. A direct correlation between the microcirculation coefficient and degree of tumor-induct pathomorphosis of tumor cells was established. The coefficient values proved to have predictive character to chemotherapy