Experimental radio-osteonecrosis in rhesus macaque jaws; therapeutic irradiation dose effect on dental extraction wound healing

Abstract Varying degrees of osteonecrosis result from molar extractions or other oral surgical procedures in rhesus macaques before, during, or after the administration of 6000 rad (the equivalent of human therapeutic dose levels) via either 240 kVp x‐ray or cobalt 60 irradiation to the jaw areas subjected to surgery. The effects of various experimental time‐dose‐wound combinations on the level of impairment of wound‐healing, interruption of osteogenesis, and the nature of the response of the irradiation‐compromised tissues are covered in this report.