Published 1988 | Version v1
Journal article Metadata-only

Preparation of a new 18F-labelled precursor: 1-[18F]fluoro-2-pyridone

Creators

  • 1. Deutsches Krebsforschungszentrum, Heidelberg (Germany, F.R.). Inst. fuer Nuklearmedizin

Description

The new 18F-labelled precursor 1-[18F]fluoro-2-pyridone was prepared by reacting [18F]F2 with 2-(trimethylsiloxy)pyridine. This compound has potential as an easy to use yet selective labelling reagent in preparations, where fluorine carrier may be tolerated. Pure (> 92%) 1-[18F]fluoro-2-pyridone is obtained within 35 min from end of bombardment in yields of up to 48%. Quality control consisted of HPLC combined with 19F-NMR spectroscopy. The mean specific activity of several preparations was 4 MBq/μmol (ε = 16.6). The precursor may be used directly or purified by sublimation. (author)

Additional details

Publishing Information

Journal Title
Appl. Radiat. Isot.
Journal Volume
39
Journal Issue
7
Series
Appl. Radiat. Isot.
Journal Page Range
685-688
CODEN
ARISE

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
19091734
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHEMICAL PREPARATION; FLUORINE 18; LABELLING; NMR SPECTRA; ORGANIC FLUORINE COMPOUNDS; PRECURSOR; PYRIDINES; RADIOPHARMACEUTICALS
Descriptors DEC
AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; DRUGS; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SPECTRA; SYNTHESIS