Effects of UV-irradiation on the SCE frequency in human lymphocyte cultures
Description
UV-irradiation (254 nm) was found to induce a smaller increase of sister chromatid exchanges (SCE) in human lymphocytes than in human fibroblasts and CHO cells. The UV-induced SCE frequency in human lymphocytes was not influenced by the duration between irradiation and the subsequent S-phase. UV-irradiated lymphocytes showed a slightly more than additive response to the SCE-inducing effect of HN2 and acetaldehyde in comparison with non-irradiated cells. The UV-induced SCE frequency was similar in lymphocyte cultures containing 20 and 100 μM of BrdUrd. The results suggest that human lymphocytes are relatively insensitive to the SCE-inducing effect of UV-irradiation, and that SCE-inducing damage caused by UV is not removed during the G1 phase in these cells. (Auth.)
Additional details
Publishing Information
- Journal Title
- Mutat. Res. Lett.
- Journal Volume
- 175
- Journal Issue
- 2
- Series
- Mutat. Res. Lett.
- Journal Page Range
- 83-89
- ISSN
- 0165-7992
- CODEN
- MUREA
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 18031359
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CHO CELLS; FIBROBLASTS; GENETIC RADIATION EFFECTS; LYMPHOCYTES; MAN; MITOSIS; NEAR ULTRAVIOLET RADIATION; SISTER CHROMATID EXCHANGES
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CELL DIVISION; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; LEUKOCYTES; MAMMALS; MATERIALS; MUTATIONS; PRIMATES; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS; ULTRAVIOLET RADIATION; VERTEBRATES
Optional Information
- Notes
- 19 refs.; 7 tabs.