Published 1982 | Version v1
Journal article Metadata-only

Action spectrum for the in vitro induction of simian virus 40 by ultraviolet radiation

Creators

  • 1. Bureau of Radiological Health, Rockville, MD (USA). Food and Drug Administration
  • 2. Louisville Univ., KY (USA). Dept. of Biology
  • 3. Western Kentucky Univ., Bowling Green (USA). Dept. of Physics
  • 4. Western Kentucky Univ., Bowling Green (USA). Dept. of Biology

Description

A line of simian virus 40-transformed hamster kidney cells was exposed to ultraviolet radiation at eleven different wavelengths in the region 238-302 nm. An action spectrum derived from the resulting exposure-response curves for the induction of simian virus 40 from these cells exhibits a broad peak in the region 260-270 nm suggesting DNA as the major chromophore for this response. This conclusion is consistent with results obtained by other investigators who have noted viral induction by a number of DNA-damaging agents. (orig.)

Additional details

Publishing Information

Journal Title
Mutat. Res.
Journal Volume
95
Series
CODEN: MUREA.;Mutat. Res.
Journal Page Range
95-103
ISSN
0027-5107

INIS

Country of Publication
Netherlands
Country of Input or Organization
Netherlands
INIS RN
14745729
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; DNA; DOSE-RESPONSE RELATIONSHIPS; HAMSTERS; IN VITRO; RADIOSENSITIVITY; SIMIAN VIRUS; ULTRAVIOLET RADIATION
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; ELECTROMAGNETIC RADIATION; MAMMALS; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PARASITES; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; VIRUSES