Published November 1999 | Version v1
Journal article Metadata-only

The effect of ZMS on the coupling of muscarinic receptor to G-proteins activation in rat brain

Creators

  • 1. Shanghai Second Medical Univ., Shanghai (China)

Description

The carbachol-stimulated [35S]GTP γ S binding method was used to observe the effect of ZMS, an active component from Zhimu, on the coupling of M-receptor to G-protein. the effect of ZMS on the ability of learning and memory in aged rats was also observed. It was shown that the carbachol-stimulated elevation of [35S]GTPγS binding was significantly decreased in aged rats as compared with young rats. The carbachol-induced [35S]STPγS binding showed that administration of ZMS at median or high dose have a definite elevation effect on the coupling activity of M-receptors to G-protein in brain, and this elevation was accompanied by an improvement of learning and memory ability

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
22
Journal Issue
11
Journal Page Range
p. 647-650
ISSN
0253-3219

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
31009849
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
BRAIN; LABELLING; LEARNING; MEMORY DEVICES; PROTEINS; RATS; RECEPTORS; SULFUR 35
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; ISOTOPES; LIGHT NUCLEI; MAMMALS; NERVOUS SYSTEM; NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; SULFUR ISOTOPES; VERTEBRATES