Two dynamic pictures of regional cerebral blood flow by the Xenon 133 inhalation method (application to cerebral infarction)
- 1. Hopital Neuro-Cardiologique, 69 - Lyon (France)
Description
Measurement of regional cerebral blood flow (rCBF) have been carried out with a gamma-camera and according to the xenon 133 inhalation method. The rCBF measurements are based on the initial part of corrected cerebral curves for recirculation and computed through deconvolution with the expired air curve. Hence an initial slope index corrected for recirculation can be determined by deconvolution. The calculation also allows us to estimate the regional partition coefficient of xenon between brain and blood. Reproductibility of this method of calculation is +-10% for regional cerebral area. Two rCBF pictures are given by the computer. The first type of picture represents the regional inequalities of rCBF when taking into consideration the local values of the partition coefficient. Second type of image is based on a constant value of the partition coefficient for the whole hemisphere. We make a comparison between the two types of pictures. 28 of the 50 patients studied after cerebral infarct shown significant falls of partition coefficient (from 5 to 43%) (mean value 28%+-11%)
Abstract (French)
Des mesures des debits sanguins cerebraux regionaux (D.S.C.r.) ont ete realisees avec une gamma-camera et selon la methode d'inhalation de xenon 133. Les calculs des D.S.C.r. sont fondes sur l'etude de la partie initiale des courbes cerebrales corrigees de la recirculation, par deconvolution par la courbe d'air expire. On calcule ainsi un index de pente initiale (Initial Slope Index: I.S.I.). Le calcul permet aussi une estimation du coefficient de partition regional du xenon entre sang et tissu cerebral. La reproductibilite moyenne pour les 9 zones etudiees est meilleure que 10% (+-1 sd). Cette valeur est identique a celle obtenue par les systemes multisondes. Des images dynamiques des debits sont egalement realisees par le calculateur. Le premier type d'image represente les inegalites regionales des D.S.C. avec prise en compte des valeurs locales du coefficient de partition. Le deuxieme type d'image est construit sur une valeur identique de ce coefficient pour tout l'hemisphere. On compare ces deux types d'image. Dans 28 cas sur 50 patients apres infarct cerebral, on constate un abaissement du coefficient de patition. Cet abaissement est compris entre 5 et 43% (cette valeur moyenne 24% +- 11%)Additional details
Additional titles
- Original title (French)
- Deux images dynamiques des debits sanguins cerebraux regionaux obtenues par inhalation de Xenon 133: application aux accidents vasculaires cerebraux
Publishing Information
- Journal Title
- J. Fr. Biophys. Med. Nucl.
- Journal Volume
- 5
- Journal Issue
- 3
- Series
- J. Fr. Biophys. Med. Nucl.
- Journal Page Range
- 159-167
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 13703036
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD FLOW; BRAIN; DYNAMIC FUNCTION STUDIES; INHALATION; ISCHEMIA; SCINTISCANNING; XENON 133
- Descriptors DEC
- ANEMIAS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; EVEN-ODD NUCLEI; HEMIC DISEASES; INTAKE; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SYMPTOMS; XENON ISOTOPES