Published March 2000
| Version v1
Journal article
Leukemia-associated gene rearrangements in blood mononuclear of subjects in long terms after radiation exposure
- 1. National Academy of Sciences, Kyiv (Ukraine). R.E. Kavetsky Institute of Experimental Pathology, Dept. of Leukemogenesis
- 2. Academy of Medical Sciences, Kyiv (Ukraine). Inst. of Endocrinology and Metabolism, Lab. of Hormonal Regulation of Haemopoesis I
Description
The results of electron microscopy and molecular genetic study of blood mononuclear s of 220 clean-up workers after 7-10 years since Chernobyl accident are presented. An increase of lymphocytes with altered ultrastructure of nuclei and membrane has been observed. Structural polymorphism of leukemia associated with bcr and rRNA genes has been analysed using Southern blot hybridization. Allelic polymorphism of bcr gene with allele distribution characteristic of myeloid leukemia and rearrangements of rRNA genes have been revealed in 11,5% of clean-up workers under study
Additional details
Publishing Information
- Journal Title
- Journal of Experimental and Clinical Cancer Research
- Journal Volume
- 19
- Journal Issue
- 1
- Journal Page Range
- p. 57-59
- ISSN
- 0392-9078
INIS
- Country of Publication
- Italy
- Country of Input or Organization
- Italy
- INIS RN
- 31064072
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- IONIZING RADIATIONS; LEUKEMIA; RADIATION ACCIDENTS; RADIATION DOSES; RADIATION INJURIES; RADIONUCLIDE KINETICS; ULTRASTRUCTURAL CHANGES
- Descriptors DEC
- ACCIDENTS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DISEASES; DOSES; IMMUNE SYSTEM DISEASES; INJURIES; KINETICS; MORPHOLOGICAL CHANGES; NEOPLASMS; RADIATION EFFECTS; RADIATIONS