Diagnostic value of myocardial tomographic imaging with 123I labelled BMIPP for exercise-induced angina pectoris

Objective: To evaluate the diagnostic value of resting myocardial tomographic imaging with 123I labelled BMIPP (123I-BMIPP SPECT) for exercise-induced angina pectoris by comparison with stress myocardial tomographic imaging with 201Tl(201Tl SPECT). Methods: 123I-BMIPP SPECT and 201Tl SPECT were performed in 32 patients with exercise-induced angina pectoris and 12 normal controls. Left ventricle was divided into nine segments and uptake of 201TL and 123I-BMIPP was evaluated by four classes score method (defect score, DS). Results: In the patients with angina pectoris, segments of 201Tl distribution abnormality were more than that of 123I-BMIPP. Concordant rate between DS of the 20'1Tl SPECT for detecting coronary artery stenosis were 62%, 92% and 70%, respectively, and 201Tl SPECT were 84%, 83% and 84%, respectively. Sensitivity of 123I-BMIPP SPECT was significantly lower than that of 201Tl SPECT (P < 0.05). The more branches of coronary artery stenosed, the more serious the degree of stenosis, the higher positive rate of 123I-BMIPP SPECT will be. Conclusions: The results indicated that to a certain extent, resting 123I-BMIPP SPECT may has practical clinical value for detection of coronary artery stenosis, and determination of stenotic degree in the patients with exercise-induced angina pectoris