Estimation of radiation absorbed doses for 6-18F-L-DOPA in human based on rats biodistribution
- 1. First Military Medical Univ., Guangzhou (China). Nanfang Hospital, Nanfang PET Centre
- 2. Chinese Academy of Sciences, Shanghai (China). Shanghai Inst. of Nuclear Research, Radiopharmaceutical Research Centre
Description
To estimate the radiation absorbed doses in humans due to intravenous administration of 6-18F-L-DOPA (18F-DOPA) based on rats biodistribution data and appraise the security of 18F-DOPA in humans. At 5, 30, 60, 90, 120 and 150 min after 18F-DOPA is injected into rats through a tail vein, the rats are killed by cervical fracture and biodistribution in rats are determined. Radiation dosimetry in humans are calculated on the base of activity distribution in rats and the standard MIRD method using radioactivity-time curves for humans. The kidney is the organ receiving highest dose of 22.9 pGy/Bq, the brain receives a dose of 11.8 pGy/Bq, and other organs receive doses between 9 and 18 pGy/Bq. The effective dose is estimated to be 20.5 pSv/Bq. The results demonstrate that human radiation dosimetry can be estimated to be 20.5 pSv/Bq. The results demonstrate that human radiation dosimetry can be estimated by the rats biodistribution data and provide an important data for clinical safe trial of 18F-DOPA
Additional details
Publishing Information
- Journal Title
- Journal of Isotopes
- Journal Volume
- 15
- Journal Issue
- 3
- Journal Page Range
- p. 164-167
- ISSN
- 1000-7512
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 34078747
- Subject category
- S61: RADIATION PROTECTION AND DOSIMETRY; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ACTIVITY LEVELS; ALGORITHMS; BIOLOGICAL MODELS; CHEMICAL PREPARATION; COUNTING RATES; DOPAMINE; DOSE EQUIVALENTS; FLUORINE 18; INTERNAL IRRADIATION; INTRAVENOUS INJECTION; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIOPHARMACEUTICALS; RATS; WHOLE-BODY COUNTING
- Descriptors DEC
- AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; COUNTING TECHNIQUES; DOSES; DRUGS; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INJECTION; INTAKE; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; MATHEMATICAL LOGIC; NANOSECONDS LIVING RADIOISOTOPES; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PHENOLS; POLYPHENOLS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SYMPATHOMIMETICS; SYNTHESIS; VERTEBRATES