Published August 19, 1986 | Version v1
Journal article Metadata-only

Interactions of furocoumarins with subunits of cell constituents. Photoreaction of fatty acids and aromatic amino acids with trimethylpsoralen (TMP) and 8-methoxypsoralen (8-MOP)

Creators

  • 1. Akademie der Wissenschaften der DDR, Jena. Zentralinstitut fuer Mikrobiologie und Experimentelle Therapie
  • 2. John Hopkin Univ., Baltimore (USA). School of Hygiene and Public Health

Description

The furocoumarin derivatives trimethylpsoralen (TMP) and 8-methoxypsoralen (8-MOP) sensitized the photoreaction of unsaturated fatty acids more slowly than histidine and faster than deoxyguanosine. Intermediacy of singlet oxygen in the furocoumarin-sensitized photoreaction of unsaturated fatty acids has been ruled out on the basis of the results of a competitive kinetics analysis. The fatty acid photoproducts have been isolated by HPLC and partially characterized. The generation of a fatty acid-TMP photoproduct is discussed. (author)

Additional details

Publishing Information

Journal Title
Stud. Biophys.
Journal Volume
114
Journal Issue
1-3
Series
Stud. Biophys.
Journal Page Range
139-148
ISSN
0081-6337
CODEN
STBIB

Conference

Title
7. CMEA symposium on biophysics of nucleic acids and proteins.
Dates
2-6 Dec 1985.
Place
Brno (Czechoslovakia).

INIS

Country of Publication
Germany
Country of Input or Organization
German Democratic Republic
INIS RN
18005443
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CARBOXYLIC ACIDS; CELL CONSTITUENTS; GUANOSINE; HISTIDINE; LIQUID COLUMN CHROMATOGRAPHY; NEAR ULTRAVIOLET RADIATION; PHOTOSENSITIVITY; PSORALEN
Descriptors DEC
AMINO ACIDS; ANTICOAGULANTS; AZOLES; CHROMATOGRAPHY; DRUGS; ELECTROMAGNETIC RADIATION; HEMATOLOGIC AGENTS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; NUCLEOSIDES; NUCLEOTIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PURINES; RADIATIONS; RIBOSIDES; SENSITIVITY; SEPARATION PROCESSES; ULTRAVIOLET RADIATION