Characterization of lymphokine-activated killer cells from peripheral blood and lymph nodes of non-Hodgkin's lymphoma patients
- 1. Immunology Division, Cancer Research Institute, Parel, Bombay, 400012 (India)
- 2. Tata Memorial Hospital, Tata Memorial Centre, Parel, Bombay, 400012 (India)
Description
Peripheral blood lymphocytes (PBL) and lymph node lymphocytes (LNL) from non-Hodgkin's lymphoma patients were tested for lymphokine-activated killer cells (LAK) cells cytotoxicity using appropriate targets in a short-term 51chromium-release assay. The results showed a significant depression in LNL-LAK activity suggesting the reduced capacity of LNL to generate LAK cells. LNL-LAK cells demonstrated significantly low percentages of cells expressing CD16, CD56 and CD25 as compared to PBL-LAK and healthy donors. The reduced capacity to generate LAK cells in lymph nodes could by due to the presence of low numbers of natural killer cells which are thought to be the main precursors of LAK cells. The IL-2 producing ability of lymph node mononuclear cells was found to by significantly higher than that of peripheral blood mononuclear cells from both healthy donors and and NHL patients. (author)
Additional details
Publishing Information
- Journal Title
- Neoplasma
- Journal Volume
- 40
- Journal Issue
- 1
- Journal Page Range
- p. 15-20
- ISSN
- 0028-2685
INIS
- Country of Publication
- Slovakia
- Country of Input or Organization
- Slovakia
- INIS RN
- 29060746
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Numerical Data, Bibliography
- Descriptors DEI
- AUTORADIOGRAPHY; BIBLIOGRAPHIES; CHROMIUM 51; CHROMIUM COMPOUNDS; DIAGNOSIS; EXPERIMENTAL DATA; IMMUNITY; LABELLED COMPOUNDS; LABELLING; LYMPH NODES; LYMPHATIC SYSTEM; LYMPHOCYTES; LYMPHOKINES; LYMPHOMAS; NUCLEAR MEDICINE; RADIOIMMUNOASSAY; RADIONUCLIDE KINETICS; THYMIDINE; TRACER TECHNIQUES; TRITIUM; UPTAKE
- Descriptors DEC
- ANIMAL CELLS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHROMIUM ISOTOPES; CONNECTIVE TISSUE CELLS; DATA; DAYS LIVING RADIOISOTOPES; DISEASES; DOCUMENT TYPES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; IMMUNE SYSTEM DISEASES; IMMUNOASSAY; INFORMATION; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; LEUKOCYTES; LIGHT NUCLEI; LYMPHATIC SYSTEM; MATERIALS; MEDICINE; NEOPLASMS; NUCLEI; NUCLEOSIDES; NUCLEOTIDES; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIOASSAY; RADIOISOTOPES; RIBOSIDES; SOMATIC CELLS; TRACER TECHNIQUES; TRANSITION ELEMENT COMPOUNDS; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- 3 tabs., 34 refs.