Intratumoral distribution of 64Cu-ATSM and 18F-FDG in VX2 tumor bearing rabbit model

Imaging acquisition and analysis of hypoxic region within solid tumor is essential for understanding the microenvironment of tumor, and is also important for the establishment of proper therapeutic strategy and evaluation for radiation therapy (1-5). 64Cu-labeled diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM) is a promising agent for imaging of hypoxic tissues and internal radiation therapy for tumor. In this study, we obtained PET/CT images of tumor using 64Cu-ATSM and 18F-FDG, and then evaluated the distribution of hypoxic region after comparing with oxygen partial pressure in VX2 tumor bearing rabbit model. MR images are also obtained for precise anatomical information