Published May 1998 | Version v1
Journal article Metadata-only

Detection of DNA-protein cross-links by 131I post labelling method

Creators

  • 1. Fujian Medical Univ., Fuzhou (China). Dept. of Nuclear Medicine
  • 2. Fujian Medical Univ., Fuzhou (China). Nutritive Hygiene

Description

131I post labelling method is developed to detect DNA-protein cross-links (DPCs) induced by environmental contaminants and carcinogens in the level of whole animal. The results demonstrate that RATS liver DPCs caused by carcinogens-aflatoxin B1(AFB1) and nitrosamine in food can be examined simply, effectively, rapidly and sensitively using the established optimum reaction conditions of 131I post labelling method. This reveals favorable prospects of 131I post labelling method to detect widely DPCs

Additional details

Publishing Information

Journal Title
Journal of Isotopes
Journal Volume
11
Journal Issue
2
Journal Page Range
p. 80-84
ISSN
1000-7512

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
29049934
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
AFLATOXINS; AMINES; CARCINOGENESIS; CROSS-LINKING; DIAGNOSIS; DNA; HAZARDOUS MATERIALS; IODINE 131; LABELLING; MUTAGENS; NITRO COMPOUNDS; PROTEINS; RATS; TEMPERATURE DEPENDENCE; TIME DEPENDENCE
Descriptors DEC
ANIMALS; ANTIGENS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; DAYS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; MYCOTOXINS; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PATHOGENESIS; POLYMERIZATION; RADIOISOTOPES; RODENTS; TOXINS; VERTEBRATES