The PZC-based Tc-99m generator preparation and its performance test

This paper described the preparation of Tc-99m generator prepared with Japan distributing Mo adsorbent PZC and irradiated nature MoO3 and its performance test. Four Tc-99m generators were prepared with different batches of PZC and reactor irradiated nature MoO3. The adsorption capacity of PZC to Mo is approximately 200mgMo/gPZC. The adsorption efficiency of three batches PZC is good (>90%) and that of one batch of PZC is not good enough (∼83%). The loss of fine powder (The PZC is fragile) is quite different with the different preparation process of PZC. The elution efficiency is 80-90% and has the up trend with the elution date. The Mo breakthrough can be controlled to acceptable level by connecting HZO safe column containing 1.0g HZO. All the specifications of eluted from PZC-based Tc-99m generator can meet the requirements under Sodium Pertechnetate injection in China Pharmacopoeia. (author)