Thermal methods in partitioning and release of anticancer drugs in colloidal nonionic surfactant vesicles niosomes: mechanistic insights

Vesicular systems such as niosomes provide an alternative to improve drug delivery vehicles. Niosomes and liposomes are similar in terms of their structure and physical properties having applications in food, pharmaceutical and cosmetic industries. The efficiency of a drug delivery vehicle is strongly dependent on its components which decide its interaction with partitioned drug(s) and locus of site of partitioning. In order to obtain quantitative insights into partitioning and release of drugs (mitoxantrone and ketoprofen) in niosomes, ultrasensitive calorimetry, spectroscopy and microscopy have been employed to establish structure-function energetics relationships which could provide guidance towards rational drug design and choice of suitable nonionic surfactant based drug delivery vehicles. The study was focused on drug partitioning in already prepared niosomes, and drug release from niosomes with partitioned drugs in the layers of vesicles