Published July 1988
| Version v1
Journal article
Preparation of 11C-nitromethane and an example of its use as a radiolabeling precursor
- 1. Karolinska Sjukhuset, Stockholm (Sweden)
- 2. Karolinska Pharmacy, Stockholm (Sweden)
- 3. Uppsala Univ. (Sweden). Dept. of Organic Chemistry
Description
No-carrier-added 11C-nitromethane has been prepared from 11C-methyl iodide in a one-pot reaction by use of silver or sodium nitrite in different solvents. A conversion of up to 87% was obtained within 3 min. It could easily be distilled from high-boiling solvents to another reaction vessel (1400C, 3 min). Its potential as a radiolabeling precursor in condensations with aldehydes was shown in the synthesis of 11C-β-nitrostyrene (85% conversion after 3-5 min). (author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 25
- Journal Issue
- 7
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 749-758
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 20005296
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 11; CHEMICAL PREPARATION; LABELLING; NITROMETHANE; PRECURSOR; RADIOPHARMACEUTICALS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHEMICAL EXPLOSIVES; DRUGS; EVEN-ODD NUCLEI; EXPLOSIVES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NITRO COMPOUNDS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS