Evaluation of serum 8-isoprostane levels and arterial stiffness index in normotensive, prehypertensive and hypertensive subjects

Objective: To compare serum levels of 8- isoprostane and arterial stiffness index (ASI) in normotensive, prehypertensive and hypertensive subjects and to ascertain its correlation with ASI and blood pressure. Methodology: We studied a total of ninety male subjects ranging from 35-55 years of age. They were classified into normotensive, prehypertensive and hypertensive groups in light of Each group comprised of thirty subjects. Blood pressure was measured with mercury sphygmomanometer and digital volume pulse was recorded by photoplethysmography and ASI was calculated. Serum 8-isoprostane levels were measured by ELISA. Results: Serum 8-isoprostane levels and ASI were significantly (0.0001) different amongst the three groups. The Post Hoc Tukey's Test revealed p-value of 0.006 between normotensive and prehypertensive groups and 0.0001 between JNC-8 Guidelines. (author)