Published November 2003 | Version v1
Journal article Metadata-only

Preparation and biodistribution of 99Tcm mixed ligand complexes containing a tridentate N-(o-methylthiophenyl)-β-mercaptoacetamide and monodentate thiols

Creators

  • 1. Beijing Forestry Univ., Beijing (China). College of Basic Science and Technology
  • 2. Beijing Normal Univ., Beijing (China). Dept. of Chemistry

Description

A novel compound, N-(o-methylthiophenyl)-β-mercaptoacetamide (MTPMA), as a tridentate ligand, was synthesized and characterized by IR, 1HNMR, MS(FAB+) and elemental analysis. Two 99Tcm mixed-ligand complexes of 99Tcm(L3,L1a) and 99Tcm(L3,L1b) were produced by ligand exchange reaction. At the same time, the optimized conditions for labelling were obtained. At these conditions, the radiochemical purity of both complexes was better than 90% and they were stable over 6 h at room temperature. Biodistribution study showed that both complexes can penetrate the blood-brain barrier and exhibit retention in mice's brain

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
26
Journal Issue
11
Journal Page Range
p. 863-867
ISSN
0253-3219

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
35052423
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BLOOD; BLOOD-BRAIN BARRIER; BRAIN; COMPLEXES; INFRARED SPECTRA; ION EXCHANGE; LABELLING; LIGANDS; MASS SPECTRA; MICE; NMR SPECTRA; RETENTION; SYNTHESIS; TECHNETIUM 99; THIOLS; TISSUE DISTRIBUTION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CENTRAL NERVOUS SYSTEM; DISTRIBUTION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; SPECTRA; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES