The temperature dependence of the induction of chromosome aberrations in human lymphocytes by means of high energy electron radiation
Description
For the irradiation of whole blood samples in vitro a linear accelerator was used. The average electron energy at the position of the blood sample was about 5 MeV. For the irradiation temperature 10 different values between 40C and 370C were chosen. For comparison blood samples from the same donator were irradiated according to an already known technique at the same temperature interval with 150 kV X-radiation. The yield of dicentric chromosomes with electron irradiation showed a similar, S-formed temperature dependence like the one with x-radiation. The lymphocytes showed with both radiation types as well an S-shaped temperature dependence of the total of all acentric fragments as well as of the so-called extra-acentric fragments, which do not associate with dicentric chromosomes, and of fragments of cells without structural chromosome aberrations. (orig./MG)
Availability note (English)
Available from the library of Goettingen Univ. (Germany, F.R.).Abstract (German)
Zur Bestrahlung von Vollblutproben in vitro diente ein Elektronen-Linearbeschleuniger. Die mittlere Elektronenenergie am Ort der Blutprobe betrug etwa 5 MeV. Fuer die Bestrahlungstemperatur wurden 10 verschiedene Werte zwischen 40C und 370C gewaehlt. Zum Vergleich wurden nach einer bereits bekannten Technik Blutproben des gleichen Spenders im gleichen Temperaturintervall mit 150 kV-Roentgenstrahlen bestrahlt. Die Ausbeute an dizentrischen Chromosomen zeigte bei Elektronenbestrahlung eine aehnliche, S-foermige Temperaturabhaengigkeit wie bei Roentgenbestrahlung. Die Lymphozyten zeigten bei beiden Strahlenarten ausserdem eine S-foermige Temperaturabhaengigkeit der Gesamtheit aller azentrischen Fragmente sowie der nicht mit dizentrischen Chromosomen assoziierten, sogenannten extra-azentrischen Fragmente und des Bruchteils an Zellen ohne strukturelle Chromosomenaberrationen. (orig./MG)Additional details
Additional titles
- Original title (German)
- Temperaturabhaengigkeit der Induktion von Chromosomenaberrationen in menschlichen Lymphozyten durch hochenergetische Elektronenbestrahlung
Publishing Information
- Imprint Pagination
- 64 p.
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 19087975
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Thesis, Non-conventional Literature
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BLOOD; CHROMOSOMAL ABERRATIONS; ELECTRON BEAMS; EXTERNAL IRRADIATION; IN VITRO; LINEAR ACCELERATORS; MEV RANGE 01-10; TEMPERATURE DEPENDENCE; X RADIATION
- Descriptors DEC
- ACCELERATORS; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BODY FLUIDS; ELECTROMAGNETIC RADIATION; ENERGY RANGE; IONIZING RADIATIONS; IRRADIATION; LEPTON BEAMS; MATERIALS; MEV RANGE; MUTATIONS; PARTICLE BEAMS; RADIATION EFFECTS; RADIATIONS