RI and Target recovery system of Lanthanides

Separation of adjacent lanthanides is complicated process to obtain pure target nuclide. Several papers have reported that the ionic character change of lanthanides with appropriate chelating agents can isolate the target lanthanides. These specific agents to the metal ion are called as complexing agents including-HIBA, tartaric acid, mandelic acid, lactic acid etc. Radioisotope research division of KAERI has developed separating technique for target lanthanides, total 20mg scale, by using complexing agents and ion-pairing agents in cold state. The reactor-produced radiolanthanides have been pivotal for development of therapeutic radiopharmaceuticals. Some radiolanthanides show excellent theranostic effects in that they have proper Let (Linear Energy Transfer) to induce apoptosis for cancer treatment and gamma ray to use as a tracer for cancer diagnosis. This system was designed for automated separation of the (n,γ) reaction product. Especially, we are focused on getting the carrier free Ho-166 which is the first attempt at KAERI. Even though we have already developed to produce c.a Ho-166(carrier added form), we did not try to develop to produce carrier free Ho-166 since the separating process is difficult as well as production process follows double (n,γ) reaction. After HANARO is re-operated, we are schedule to produce n.c.a Ho by using this recovery system