An automated radiosynthesis of (S)-[18F]28 for PET imaging of Alzheimer's disease

Highlights: • A concise and facile fully automatic synthesis of (S)-[¹⁸F]28 was proposed. • A commercially available AllinOne radiosynthesis module was used for production. • The non-decay corrected radiochemical yield were 36 ± 1.9% with >95% radiochemical purity in less than 60 min. • Facilitating the widespread use of (S)-[¹⁸F]28 in large-scale clinical trials. ¹⁸F-labeled 2-arylbenzoxazole derivative (S)-[¹⁸F]28 is potent and selective radiopharmaceutical Aβ tracers for Alzheimer's disease positron-emission tomography (PET). Our study aimed to enable facile preparation of (S)-[¹⁸F]28 in commercially available PET tracer production facilities to promote the widespread application and clinical translation. Here, we successfully demonstrated an automated radiosynthesis of (S)-[¹⁸F]28 with high radiochemical yield and radiochemical purity by the AllinOne radiosynthesis module. The method developed here can facilitate extensive use of (S)-[¹⁸F]28 in large-scale clinical trials.