R2 and R2* MRI assessment of liver iron content in an undifferentiated diagnostic population with hyperferritinaemia, and impact on clinical decision making

Highlights: • R2* is accurate in hyperferritinaemia, and highly correlated with R2 (Ferriscan®). • R2 and R2* MRI results altered clinical management in >44 % of patients with hyperferritinaemia. • R2* has advantages over R2, particularly simultaneous production of a PDFF map. To confirm the linear correlation between Ferriscan® R2 (1/T2 Relaxomatry) and R2* (1/T2* Relaxometry) derived 3D Gradient echo (GRE) mDIXON-Quant sequence (Philips) with simultaneous production of a proton density fat fraction (PDFF) in undifferentiated patients with hyperferritinaemia, and to prospectively determine the clinical utility of this tool in these patients by recording the impact on clinical decision-making.