Subjective and objective comparisons of image quality between ultra-high-resolution CT and conventional area detector CT in phantoms and cadaveric human lungs

To compare the image quality of the lungs between ultra-high-resolution CT (U-HRCT) and conventional area detector CT (AD-CT) images. Image data of slit phantoms (0.35, 0.30, and 0.15 mm) and 11 cadaveric human lungs were acquired by both U-HRCT and AD-CT devices. U-HRCT images were obtained with three acquisition modes: normal mode (U-HRCT_N: 896 channels, 0.5 mm x 80 rows; 512 matrix), super-high-resolution mode (U-HRCT_SHR: 1792 channels, 0.25 mm x 160 rows; 1024 matrix), and volume mode (U-HRCT_SHR-VOL: non-helical acquisition with U-HRCT_SHR). AD-CT images were obtained with the same conditions as U-HRCT_N. Three independent observers scored normal anatomical structures (vessels and bronchi), abnormal CT findings (faint nodules, solid nodules, ground-glass opacity, consolidation, emphysema, interlobular septal thickening, intralobular reticular opacities, bronchovascular bundle thickening, bronchiectasis, and honeycombing), noise, artifacts, and overall image quality on a 3-point scale (1 = worst, 2 = equal, 3 = best) compared with U-HRCT_N. Noise values were calculated quantitatively. U-HRCT could depict a 0.15-mm slit. Both U-HRCT_SHR and U-HRCT_SHR-VOL significantly improved visualization of normal anatomical structures and abnormal CT findings, except for intralobular reticular opacities and reduced artifacts, compared with AD-CT (p < 0.014). Visually, U-HRCT_SHR-VOL has less noise than U-HRCT_SHR and AD-CT (p < 0.00001). Quantitative noise values were significantly higher in the following order: U-HRCT_SHR (mean, 30.41), U-HRCT_SHR-VOL (26.84), AD-CT (16.03), and U-HRCT_N (15.14) (p < 0.0001). U-HRCT_SHR and U-HRCT_SHR-VOL resulted in significantly higher overall image quality than AD-CT and were almost equal to U-HRCT_N (p < 0.0001). Both U-HRCT_SHR and U-HRCT_SHR-VOL can provide higher image quality than AD-CT, while U-HRCT_SHR-VOL was less noisy than U-HRCT_SHR. (orig.)