Published December 2018 | Version v1
Journal article Metadata-only

Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1 / DDAH / PPAR-γ/ eNOS pathways in streptozotocin-induced diabetic rats

Creators

  • 1. Department of Urology, Shandong Zaozhuang Municipal Hospital, Zaozhuang, 277000 (China)
  • 2. Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021 (China)

Description

Diabetic erectile dysfunction (DMED) is mainly attributed to oxidative stress, and Nrf2 plays an important role in cellular antioxidation and regulates NO production in the vascular endothelium. Probucol maintains endothelial function through its antioxidant activity. This study investigated the efficacy and mechanism of probucol in improving erectile function in streptozotocin-induced diabetic rats.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.bbrc.2018.10.036

Additional details

Identifiers

DOI
10.1016/j.bbrc.2018.10.036;
PII
S0006291X18321831;

Publishing Information

Journal Title
Biochemical and Biophysical Research Communications
Journal Volume
507
Journal Issue
1-4
Journal Page Range
p. 9-14
ISSN
0006-291X
CODEN
BBRCA9

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
53051525
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ANTIOXIDANTS; DIABETES MELLITUS; DME; ENDOTHELIUM; RATS; STREPTOZOCIN
Descriptors DEC
ANIMAL TISSUES; ANIMALS; ANTIBIOTICS; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC DRUGS; BODY; DISEASES; DRUGS; ENDOCRINE DISEASES; ETHERS; MAMMALS; METABOLIC DISEASES; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; RODENTS; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2018 Elsevier Inc. All rights reserved.