Published 1974 | Version v1
Book Metadata-only

Transformation of nonvirus producing BALB/3T3 cells by an environmental extract

Creators

  • 1. Columbus Labs., OH

Description

Nonvirus-producing BALBc/3T3 murine cell cultures were shown to be susceptible to morphological transformation by a soot extract. This extract, based on benzo(a)pyrene (BaP) content, was several thousand times more potent in transforming cells than was pure BaP. The increased activity of the soot extract was not due to induction of an endogenous 'C' type virus. Chemical analysis identified several polycyclic aromatic hydrocarbon (PAH) carcinogens. Based on their contribution to the total content of the extract, it appears that the increased transforming activity of the soot was due to either synergistic action between the PAHs or the presence of noncarcinogenic promoting agents

Additional details

Additional titles

Augmented title (English)
Effects of soot extract on murine cells

Publishing Information

Publisher
Springer-Verlag New York Inc.
Imprint Place
New York
Imprint Title
Experimental lung cancer: carcinogenesis and bioassays
Imprint Pagination
p. 583-589.

Conference

Title
Symposium on experimental respiratory carcinogenesis and bioassays.
Dates
23 Jun 1974.
Place
Seattle, Washington, USA.

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
7268581
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ANIMAL CELLS; BENZOPYRENE; BIOLOGICAL EFFECTS; CARCINOGENESIS; CELL CULTURES; CHEMICAL ANALYSIS; ENVIRONMENT; HYDROCARBONS; MICE; MORPHOLOGICAL CHANGES; POLLUTION
Descriptors DEC
ANIMALS; AROMATICS; CONDENSED AROMATICS; MAMMALS; ORGANIC COMPOUNDS; PATHOGENESIS; RODENTS; VERTEBRATES

Optional Information

Notes
Imprint:See CONF-740648--.