Published October 1985 | Version v1
Journal article Metadata-only

Synthesis and biodistribution of no-carrier-added [1-11C]putrescine

Creators

  • 1. Brookhaven National Lab., Upton, NY

Description

No-carrier-added [1-11C]putrescine was synthesized in 20% radiochemical yield in a synthesis time of 50 min by the Michael addition of potassium [11C]cyanide to acrylonitrile followed by reduction of the [11C]dinitrile with borane-methyl sulfide complex. Biodistribution in mice at 5, 30, and 60 min showed low uptake in normal brain tissue

Additional details

Publishing Information

Journal Title
J. Nucl. Med.
Journal Issue
no.10
Series
J. Nucl. Med.
ISSN
0022-3123
CODEN
JNMEA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
17042934
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BRAIN; CARBON 11; CHEMICAL PREPARATION; EMISSION COMPUTED TOMOGRAPHY; MICE; PUTRESCINE; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION
Descriptors DEC
AMINES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; CHEMISTRY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISTRIBUTION; DRUGS; EVEN-ODD NUCLEI; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SYNTHESIS; TOMOGRAPHY; VERTEBRATES