Published December 1990
| Version v1
Journal article
Radioactive synthesis of quaternary ammonium salts of hydroxyimino 2- or 4-methyl pyridinium by means of N-methyl 14C-formanilide: Pt. 2
Creators
- 1. Institut National de la Sante et de la Recherche Medicale (INSERM), 63 - Clermont-Ferrand (France)
- 2. CEB Le Bouchet, 91 -Vert-le-Petit (France)
- 3. Clermont-Ferrand-2 Univ., 63 - Aubiere (France)
- 4. Institut du Radium, 75 - Paris (France). Lab. Curie
- 5. Direction des Recherches et Techniques, 75 -Paris (France). Delegation Generale pour l'Armement
Description
The two compounds were labelled by 14C on the hydroxyimino methyl group substituted on the 2 positions of the pyridinium ring. The convenient pyridinium lithiated intermediates were formylated with N-methyl 14C-formanilide. The hydroxyimino methyl groups were synthezised by reaction of the 14C-formyl compound with hydroxylamine. For the two species alkylation of pyridine was performed with methyliodide. Radiochemical yields were 50% and 20%. (author)
Additional details
Additional titles
- Subtitle (English)
- Sup(14)C labelling of 1-[hydroxyimino 2-methyl 1-methyl] pyridinyl iodide, or 2-PAM iodide, and of trimethylene 3,3'-dioxy bis [hydroxyimino 2-methyl 1-methyl, pyridinyl] diiodide, or R-665
- Original title (French)
- Synthese radioactive de sels d'ammonium quaternaires d'hydroxy imino methyl-2 ou-4 pyridinyle par l'intermediaire de la N-methyl formanilide-
- Original subtitle (French)
- Marquage par "1"4C de l'iodure d'[hydroxyimino methyl-2 methyl-1 pyridinyle] ou 2-PAM lodure et du diodure de trimethylene dioxy-3,3' bis [hydroxy imino methyl-2 methyl-1, pyridinyle] ou R-665.
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 28
- Journal Issue
- 12
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 1385-1392
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 22054384
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 14 COMPOUNDS; CHEMICAL PREPARATION; CHOLINESTERASE; ENZYME ACTIVITY; LABELLING; PYRIDINES; QUATERNARY COMPOUNDS; RADIOPHARMACEUTICALS
- Descriptors DEC
- AMINES; AZINES; CARBON COMPOUNDS; CARBOXYLESTERASES; DRUGS; ENZYMES; ESTERASES; HETEROCYCLIC COMPOUNDS; HYDROLASES; LABELLED COMPOUNDS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; SYNTHESIS