Published September 1982
| Version v1
Journal article
Dipyrone-induced changes in DNA repair and other cell membrane associated processes in Escherichia coli
Creators
- 1. Bhabha Atomic Research Centre, Bombay (India). Biochemistry and Food Technology Div.
Description
The analgesic, dipyrone (1,phenyl-2,3-dimethyl-5-pyrazolone-4-methylamino methane sulphonate sodium), at 20 mM concentration, inhibited the rejoining of single-strand scissions in DNA of Escherichia coli B/r cells induced by 20 krad gamma-radiation. The chemical altered the cell membrane structure as evidenced from the uptake of acriflavin, the efflux of potassium ions from the bacterial cells and the inhibition of alkaline phosphatase-a cell membrane associated enzyme. (author)
Additional details
Publishing Information
- Journal Title
- J. Biosci.
- Journal Volume
- 4
- Journal Issue
- 3
- Series
- J. Biosci.
- Journal Page Range
- 317-326
- ISSN
- 0250-5991
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 16084638
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ALKALINE PHOSPHATASE; ANALGESICS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; CELL MEMBRANES; DNA; ESCHERICHIA COLI; GAMMA RADIATION; INHIBITION; LABELLED COMPOUNDS; LABELLING; STRAND BREAKS; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS
- Descriptors DEC
- AZINES; BACTERIA; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; CELL CONSTITUENTS; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESS; DRUGS; ELECTROMAGNETIC RADIATION; ENZYMES; ESTERASES; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; HYDROLASES; IONIZING RADIATIONS; ISOTOPE APPLICATIONS; MEMBRANES; MICROORGANISMS; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHOSPHATASES; PHOSPHOHYDROLASES; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RIBOSIDES
Optional Information
- Notes
- 18 refs., 6 figures.