Preliminary findings in the evaluation of hepatic malignancies by radioimmunodetection, X-ray computed tomography, and magnetic resonance imaging

In 12 consecutive patients with suspected metastatic carcinoma of the liver, we evaluated the sensitivty of radiolabeled antibodies to tumor antigens, magnetic resonance imaging, and X-ray computed tomography imaging in the detection of hepatic malignancies. Studies were performed with 131I labeled antibodies to CEA and/or CSAp; polyclonal, monoclona and F(ab')2 antibodies were used. Nontarget radioactivity was diminished by administration of 99mTc reagents simulating nontumor distribution and use of a computer substraction method. In nine patients with confirmed liver neoplasms, radioimmunodetection disclosed the foci of hepatic malignancies. In three patients with suspected liver neoplasms, the antibody studies were positive, but at this time have not been confirmed, X-ray computed tomography each disclosed mass lesions in five patients and magnetic resonance in three. These findings suggest that radiommunodetection provides greater accuracy in the detection and localization of cancer than other diagnostic modalities currently used. (orig.)