One-pot three-component method for the synthesis of highly functionalized 1,2,3,4-tetrahydropyridines

It is established that the three-component interaction of malonic acid arylamidoesters, aromatic aldehydes and malonic acid dinitrile proceeds at room temperature in the presence of triethylamine with the formation of alkyl 6-amino-1,4- diaryl-2-oxo-5-cyano-1,2,3,4-tetrahydropyridine-3-arboxylates with yields of 47-98%. According to NMR spectroscopy data, if the aromatic ring of the amide part contains an ortho-substituent in these compounds, they exist in the solution as two rotamers.