Published November 1990
| Version v1
Journal article
Investigation of the repair of single-strand breaks in human DNA using alkaline gel electrophoresis
Description
Unstimulated lymphocytes from eight healthy persons were exposed to 10-, 30-, and 100-Gy doses of 60Co gamma radiation. The repair of damaged DNA was measured by (1) alkaline gel electrophoresis (extracted DNA loaded on 0.25% agarose gel, run at 1 V/cm for 39-44 h) at 0, 1, and 2 h after exposure and (2) incorporation of [3H]thymidine into unstimulated lymphocytes in the presence of 2 mM hydroxyurea 1 and 2 h after exposure. Both methods--alkaline gel electrophoresis and thymidine incorporation--showed that repair was completed within 2 h
Additional details
Publishing Information
- Journal Title
- Radiation Research
- Journal Volume
- 124
- Journal Issue
- 2
- Series
- Radiat. Res.
- Journal Page Range
- 137-140
- ISSN
- 0033-7587
- CODEN
- RAREA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 22028366
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; COBALT 60; DNA REPAIR; ELECTROPHORESIS; GAMMA RADIATION; GENE REGULATION; IN VITRO; LYMPHOCYTES; MAN; RADIATION EFFECTS; STRAND BREAKS; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BLOOD; BLOOD CELLS; BODY FLUIDS; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LEUKOCYTES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEOSIDES; NUCLEOTIDES; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PRIMATES; PYRIMIDINES; RADIATIONS; RADIOISOTOPES; RIBOSIDES; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES