Published February 19, 1983 | Version v1
Journal article Metadata-only

Gastroduodenal motility

Creators

  • 1. University of the Witwatersrand, Johannesburg (South Africa). Dept. of Surgery

Description

Domperidone (Motilium) speeds the emptying rate of the smallest particle size of a digestible solid (radioactive cubed liver) but has no effect on the emptying rate of 400 ml of 5% dextrose in the normal canine stomach. Conversely, metoclopramide (Maxolon) speeds the emptying of the liquid, but slows the emptying rate of the digestible solid. The effect of domperidone on canine gastric electrical activity is to increase the frequency and strenght of action potentials in the stomach after fasting and to slow the rate of discharge of the pacesetter potential, an effect similar to that seen after feeding

Additional details

Additional titles

Subtitle (English)
A comparison between domperidone and metoclopramide

Publishing Information

Journal Title
S. Afr. Med. J.
Journal Volume
63
Journal Issue
8
Series
S. Afr. Med. J.
Journal Page Range
270-273
ISSN
0038-2469

INIS

Country of Publication
South Africa
Country of Input or Organization
South Africa
INIS RN
14761666
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BARIUM; CHROMIUM 51; COBALT 57; DOGS; FEEDING; LIQUIDS; LIVER; RENAL CLEARANCE; SMALL INTESTINE; STOMACH; SURGERY; VAGUS
Descriptors DEC
ALKALINE EARTH METALS; ANIMALS; AUTONOMIC NERVOUS SYSTEM; BETA DECAY RADIOISOTOPES; BODY; CHROMIUM ISOTOPES; CLEARANCE; COBALT ISOTOPES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; EXCRETION; FLUIDS; GASTROINTESTINAL TRACT; GLANDS; INTERMEDIATE MASS NUCLEI; INTESTINES; ISOTOPES; MAMMALS; MEDICINE; METALS; NERVES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; VERTEBRATES