Determination of nanogram quantities of gold in biological tissues by nondestructive neutron activation analysis

A method for gold analysis in kidney and liver is described. The technique is simpler than other methods in that it does not require ashing or acid digestion of the sample. The tissue is dried, placed into a polyethylene vial and diluted with a 2 ml sodium chloride solution. Gold concentration is determined by neutron activation analysis. Samples are irradiated for two hours at a thermal neutron flux of 1012 nxcm-2xs-1 and are then allowed to decay for 3-4 days before counting. The detection limit (20 ng Au/ml) and precision (+- 6.1%) permits the accurate analysis of gold in these tissues. This technique could aid in a re-examination of gold metabolism. (author)